Spider-Man searches for Mary Jane Watson while the city of New York is infested with symbiotes. He finds her with Luke Cage but then sees a mysterious figure and is attacked. During a flashback to four days earlier, Spider-Man retells his account of how his latest encounter with Venom ended with a piece of the symbiote binding to himself. After the fight with Venom, an injured Mary Jane is sent to a hospital and Spidey meets Luke Cage during a gang war. Cage explains the Rolling Sevens and Park Avenue gangs are at war, and that their task is to bring the two to a truce. After pursuing the two gang leaders across the city, Spider-Man manages to get them to agree to a peaceful meeting in a park in Harlem. Outside the rendezvous point, Spider-Man discovers high-tech assassins on top of the nearby buildings. After defeating them, he traces the assassins back to the Kingpin.
Spider-Man heads to Kingpin's lair, but finds Black Cat leaving and gives chase. The two fight briefly, but in the end, Black Cat reveals she is working against Kingpin. The two join forces with Moon Knight in order to stop the Kingpin's illegal activities, battling several of his men, including the Vulture; Vulture had been mass producing Goblin gliders for Kingpin's goons to use. Eventually, Spider-Man confronts a number of Kingpin's henchman on the roof of the Daily Bugle; all are surprised by the sudden appearance of civilians that attack them with their hands and teeth. A news helicopter records Spider-Man throwing civilians off of the building, and the police believe him to be a murderer. Unknown to them, the civilians have been infected with symbiotes.
Spider-Man runs into Wolverine in Hell's Kitchen; after a battle (in which infected civilians appear), the two settle their differences and begin tracking down other infected citizens. Eventually, Spider-Man finds Venom throwing people into symbiote pods, turning them into monsters. The two engage in a cross-city battle in which Venom escapes and several of the pods are destroyed. A S.H.I.E.L.D. team led by Black Widow arrives quarantines New York and sets up symbiote controlled citizen quarantine camps. Electro rampages through the camps, looking for his sister; Widow shoots him to restore order. Electro's sister accidentally infects and heals him with the symbiote attached to her. The result is a powerful symbiote monster, who takes off before anything can be done to contain him.
Since no genius heroes are available, Spider-Man decides to break the Tinkerer out of Ryker's Island to utilize his scientific genius to find a countermeasure to the symbiotes. Upon reaching the prison, Spider-Man teams up with the Rhino, using his strength to help free the Tinkerer. The Tinkerer then designs a device that won't harm the hosts, only remove the symbiotes; it must be installed on the Trask Building for the maximum efficient sound waves. While the Tinkerer constructs the device, Spider-Man aids S.H.I.E.L.D. in dealing with the symbiote infestation in the streets of Manhattan. First, he confronts the symbiote Electro in Central Park, defeating him and stopping him from reaching the city's power supply. He then helps Wolverine in evacuating a church filled with civilians, but Wolverine ends up getting infected and attacks Spidey. Spider-Man is able to purge Wolverine of the symbiote, and then goes looking for Mary Jane.
He finds her, helping Mary Jane and Luke Cage clear out Harlem, but goes to a building invaded by symbiotes. There, he finds a symbiote possessed Black Cat, apparently the leader of the hive, and defeats her with help from Mary Jane. The Tinkerer's device is completed, but a symbiote Vulture leads an attack against the Trask Building to stop it. After defeating the Vulture, Spider-Man is confronted with a choice which is determined by the player's actions. He can activate the device, which kills the symbiotes, or become dominated by the black suit, and leave the device turned off. He then responds to an attack on the S.H.I.E.L.D. Helicarrier, which is being attacked by Venom.
Enlisting Moon Knight or Vulture (depending on the player's actions) to carry him to the Helicarrier, Spider-Man sets bombs to destroy the ship while the heroes and villains keep the infected at bay. After everyone evacuates, Spidey is confronted by Venom in the form of a monstrous five headed behemoth. Spider-Man is able to destroy four of the heads, and calls on Eddie Brock. The player can choose to either get Eddie to try and assist with destroying the symbiotes, or kill Eddie.
In the good ending, realizing the destruction that has been caused by his alter ego, Brock regains control from the symbiote and sacrifices himself to put an end to the madness. In the bad ending, Spider-man becomes dominated by the black suit and pushes Eddie towards a Helicarrier engine, killing him. The symbiote monster weakens, and the Helicarrier explodes, destroying the Venom symbiote.
Red/Hero Ending : A week after the catastrophe, Spider-Man narrates about his victory on the top of a building before swinging away with Mary Jane, to make her forget he was narrating.
Anti-hero Ending: A week after the catastrophe, Spider-man calls Mary Jane to tell her that he's sorry for his bad decisions, but she doesn't answer, so he leaves this message in her voicemail.
Anti-villain Ending: Spider-Man dominates New York's symbiotes with the power of the Black Suit.
Black/Villain Ending: Spider-Man dominates New York's symbiotes with the black suit, and with a symbiote Black Cat at his side. After this, it is revealed that Kingpin, the Tinkerer, and Black Widow have all banded together to stop Spider-Man, by unleashing a symbiote Wolverine, which Spider-Man defeats earlier in the game.
Đánh dấu